pentobarbital will lessen the extent or effect of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Contraindicated (1)pentobarbital will lessen the extent or impact of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or result of amlodipine by affecting hepatic/in